Effaclar H Iso-Biome Wash 200ml. Effaclar H Iso-Biome Cleansing Cream is a hydrating cream cleanser that gently cleanses, purifies and soothes skin feeling weakened by the drying effects of acne treatments. Effaclar H Iso-Biome face cleanser is suitable for use by those with sensitive skin, oily, and acne-prone skin.